Background: Cutaneous Leishmaniasis (CL) is an endemic disease in many countries and caused\nby different species of Leishmania parasite. It results in a deformed scar after a relatively long period.\nMany therapies have been tried in treatment of this disease. Objective: To compare the effect\nof oral zinc sulfate and oral ketoconazole singly and in combination in the treatment of acute cutaneous\nleishmaniasis. Patients and Methods: This single, blinded, therapeutic, controlled study\nwas conducted in the Department of Dermatology, Baghdad Teaching Hospital, Baghdad, Iraq,\nduring the period, January 2015 to July 2015. Seventy-five patients with acute CL were enrolled in\nthis study. The total numbers of lesions were 327, and the duration of lesions ranged from 4 to 12\n(6.9 �± 0.7) weeks. The diagnosis was confirmed by smear and histopathology. Patients were divided\ninto three groups: 24 patients in Group A were treated with oral zinc sulfate capsules 10\nmg/kg/day for 6 weeks; 24 patients in Group B were treated with ketoconazole tablets 200 mg\ntwice daily for 6 weeks and 27 patients in Group C were treated orally with a combination of zinc\nsulfate and ketoconazole for 6 weeks. All patients were seen regularly every 2 weeks for 6 weeks\nof treatment period, then monthly for the next three months as follow up period. Healing of the lesions\nwas assessed by using Sharquieâ��s modified Leishmania score to assess the objective response\nto the topical or systemic therapy. Results
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